Chromogranin A: a surprising link between granule biogenesis and hypertension.

  title={Chromogranin A: a surprising link between granule biogenesis and hypertension.},
  author={Taeyoon Kim and Y. Peng Loh},
  journal={The Journal of clinical investigation},
  volume={115 7},
Chromogranin A (CHGA) and its derived peptides, which are stored and released from dense-core secretory granules of neuroendocrine cells, have been implicated as playing multiple roles in the endocrine, cardiovascular, and nervous systems. In this issue of the JCI, Mahapatra et al. present in vivo evidence for 2 important functions of CHGA: the regulation of catecholamine-containing dense-core chromaffin granule biogenesis in the adrenal gland and the control of blood pressure. Obliteration of… CONTINUE READING
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Formation of the catecholamine release-inhibitory peptide catestatin from chromogranin A. Determination of proteolytic cleavage sites in hormone storage granules

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