Chromoendoscopic surveillance in hereditary diffuse gastric cancer: an alternative to prophylactic gastrectomy?

@article{Shaw2005ChromoendoscopicSI,
  title={Chromoendoscopic surveillance in hereditary diffuse gastric cancer: an alternative to prophylactic gastrectomy?},
  author={David M. Shaw and Vanessa Blair and Ann Framp and Pauline Harawira and M Mcleod and Parry Guilford and Susan Parry and Amanda Charlton and Ian J G Martin},
  journal={Gut},
  year={2005},
  volume={54 4},
  pages={461-8}
}
BACKGROUND Hereditary diffuse gastric cancer (HDGC) is defined by germline mutations in the E-cadherin gene, CDH-1. The first family in which CDH-1 mutations were identified was a large Maori kindred, where lifetime penetrance is 70%. Prophylactic gastrectomy is an unacceptable option for many mutation carriers. The results of annual chromoendoscopic surveillance using the methylene blue/congo red technique in 33 mutation carriers over a five year period are described. PATIENTS AND METHODS… CONTINUE READING

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