Chromobacterium pathogenicity island 1 type III secretion system is a major virulence determinant for Chromobacterium violaceum-induced cell death in hepatocytes.

@article{Miki2010ChromobacteriumPI,
  title={Chromobacterium pathogenicity island 1 type III secretion system is a major virulence determinant for Chromobacterium violaceum-induced cell death in hepatocytes.},
  author={Tsuyoshi Miki and Mirei Iguchi and Kinari Akiba and Masato Hosono and Tomoyoshi Sobue and Hirofumi Danbara and Nobuhiko Okada},
  journal={Molecular microbiology},
  year={2010},
  volume={77 4},
  pages={855-72}
}
Chromobacterium violaceum is a Gram-negative bacterium that causes fatal septicaemia in humans and animals. C. violaceum ATCC 12472 possesses genes associated with two distinct type III secretion systems (T3SSs). One of these systems is encoded by Chromobacterium pathogenicity islands 1 and 1a (Cpi-1/-1a), another is encoded by Chromobacterium pathogenicity island 2 (Cpi-2). Here we show that C. violaceum causes fulminant hepatitis in a mouse infection model, and Cpi-1/-1a-encoded T3SS is… CONTINUE READING

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