Chromium supplementation in overweight and obesity: a systematic review and meta‐analysis of randomized clinical trials

  title={Chromium supplementation in overweight and obesity: a systematic review and meta‐analysis of randomized clinical trials},
  author={Igho J. Onakpoya and Paul Posadzki and Edzard Ernst},
  journal={Obesity Reviews},
The increased prevalence of obesity has made the use of dietary supplements as weight reducing agents highly popular, but their efficacy has not been proven. One such supplement is chromium. The purpose of this review was to evaluate the evidence for or against the efficacy of chromium supplementation in overweight and obese individuals. Electronic searches were conducted in Medline, Embase, Amed and The Cochrane Library. The bibliographies of located articles were also searched. No age, gender… 
A meta‐analysis of the effect of chromium supplementation on anthropometric indices of subjects with overweight or obesity
Chromium supplementation was associated with some improvements in body composition in subjects with obesity/overweight, but the effect size was medium and the clinical relevance of chromium as a weight loss aid remains uncertain.
Effects of chromium supplementation on lipid profile in patients with type 2 diabetes: A systematic review and dose-response meta-analysis of randomized controlled trials.
  • Omid Asbaghi, F. Naeini, A. Naeini
  • Medicine
    Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements
  • 2021
A systematic review and narrative synthesis of interventions for uncomplicated obesity: weight loss, well-being and impact on eating disorders
Quality of life was the most common psychological outcome measure, and improved in all cases where it was assessed, across all intervention types, while bariatric surgery led to improvements in eating behaviour and body image that were not sustained over the long-term.
Effects of Chromium and Carnitine Co-supplementation on Body Weight and Metabolic Profiles in Overweight and Obese Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial
Overall, chromium and carnitine co-supplementation for 12 weeks to overweight women with PCOS had beneficial effects on body weight, glycemic control, lipid profiles except HDL cholesterol levels, and gene expression of PPAR-γ and LDLR.
The Effect of a New Dietary Mineral Product on Body Composition and Weight in Overweight and Obese People. The Results from a Comparative Randomized 30-Days Study
The efficacy of a new dietary mineral product based on natural ingredients based on the middle calcareous layer of oyster shells, in homeopathic and traditional medicine known as calcarea carbonica, as well as iodine, magnesium and chromium was investigated.
Chromium supplementation and polycystic ovary syndrome: A systematic review and meta-analysis.
A Dietary Supplement Containing Cinnamon, Chromium and Carnosine Decreases Fasting Plasma Glucose and Increases Lean Mass in Overweight or Obese Pre-Diabetic Subjects: A Randomized, Placebo-Controlled Trial
Four-month treatment with a dietary supplement containing cinnamon, chromium and carnosine decreased FPG and increased fat-free mass in overweight or obese pre-diabetic subjects, which might open up new avenues in the prevention of diabetes.
Chromium picolinate balances the metabolic and clinical markers in nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled trial
It was showed that consuming 400 µg/day of CrPic for 12 weeks in patients with NAFLD causes a significant change in leptin, adiponectin, oxidative stress (expect glutathione peroxidase), and body weight, compared to baseline.


Chromium picolinate for reducing body weight: Meta-analysis of randomized trials
A relatively small effect of chromium picolinate compared with placebo for reducing body weight is suggested, but the clinical relevance of the effect is debatable and the lack of robustness means that the result has to be interpreted with caution.
A pilot study of chromium picolinate for weight loss.
BACKGROUND Chromium is an essential trace element and nutritional supplement that has garnered interest for use as a weight loss aid. OBJECTIVE This trial assesses the effects of chromium
Beneficial Effect of Chromium Supplementation on Serum Triglyceride Levels in NIDDM
This is the first report of a significant reduction in serum TGs in a group of NIDDM patients treated with chromium, making it an attractive lipid-lowering agent for this population.
A Double-Blind, Placebo-Controlled, Exploratory Trial of Chromium Picolinate in Atypical Depression: Effect on Carbohydrate Craving
The results of this study suggest that the main effect of chromium was on carbohydrate craving and appetite regulation in depressed patients and that 600 μg of elemental chromium may be beneficial for patients with atypical depression who also have severe carbohydrate craving.
Effects of chromium picolinate on body composition.
It was concluded that chromium picolinate was ineffective in enhancing body fat reduction in this group and could not be recommended as an adjuvant to Navy weight-loss programs in general.
In patients with HIV-infection, chromium supplementation improves insulin resistance and other metabolic abnormalities: a randomized, double-blind, placebo controlled trial.
It is suggested that chromium supplements alleviate some of the antiretroviral-associated metabolic abnormalities in HIV+ patients, and body weight and medication profile remained stable throughout the study for both groups.
Food Supplements for Body Weight Reduction: A Systematic Review of Systematic Reviews
The objective of this overview was to summarize and critically evaluate all available systematic reviews of food supplements for body weight reduction.
The Potential Value and Toxicity of Chromium Picolinate as a Nutritional Supplement, Weight Loss Agent and Muscle Development Agent
Over a decade of human studies with Cr(pic)3 indicate that the supplement has not demonstrated effects on the body composition of healthy individuals, even when taken in combination with an exercise training programme.