Chromium (VI)-induced DNA damage in chick embryo liver and blood cells in vivo.

@article{Hamilton1986ChromiumD,
  title={Chromium (VI)-induced DNA damage in chick embryo liver and blood cells in vivo.},
  author={Joshua W. Hamilton and Karen E. Wetterhahn},
  journal={Carcinogenesis},
  year={1986},
  volume={7 12},
  pages={2085-8}
}
Uptake of chromium (VI) and subsequent induction of DNA damage was examined in liver and blood cells of 14-day chick embryos after injection of sodium dichromate onto the inner shell membrane. Maximal loss of chromium from the inner shell membrane and distribution of chromium in liver, lung and blood was observed 2 h after injection. DNA strand breaks, interstrand cross-links and DNA--protein cross-links were measured using the alkaline elution technique. In chick embryo liver, chromium (VI… CONTINUE READING