Chromium(III) picolinate produces chromosome damage in Chinese hamster ovary cells.

  title={Chromium(III) picolinate produces chromosome damage in Chinese hamster ovary cells.},
  author={Diane M. Stearns and John Pierce Wise and Steven R. Patierno and Karen E. Wetterhahn},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={9 15},
Chromium(III) complexes currently being sold as dietary supplements were tested for their ability to cause chromosomal aberrations in Chinese hamster ovary cells. Complexes were tested in soluble and particulate forms. Chromium picolinate was found to produce chromosome damage 3-fold to 18-fold above control levels for soluble doses of 0.050, 0.10, 0.50, and 1.0 mM after 24 h treatment. Particulate chromium picolinate doses of 8.0 micrograms/cm2 (corresponding to a 0.10 mM solublized dose) and… CONTINUE READING

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