Chromatography-mass spectrometry studies on the metabolism of synthetic cannabinoids JWH-018 and JWH-073, psychoactive components of smoking mixtures.

@article{Grigoryev2011ChromatographymassSS,
  title={Chromatography-mass spectrometry studies on the metabolism of synthetic cannabinoids JWH-018 and JWH-073, psychoactive components of smoking mixtures.},
  author={Andrej Grigoryev and Sergey Alexandrovich Savchuk and Aleksandra Melnik and Natal'ja Moskaleva and Jurij Dzhurko and Mihail Ershov and Aleksandr E Nosyrev and Aleksandr Vedenin and Boris N. Izotov and Irina Zabirova and Vladimir Rozhanets},
  journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  year={2011},
  volume={879 15-16},
  pages={1126-36}
}
The Russian Federation prohibited the distribution of herbal mixtures with synthetic aminoalkylindoles JWH-018 and JWH-073, agonist cannabinoid receptors, on January 22, 2010. The lack or low content of their native compounds in urine requires detailed identification of their metabolites, which are excreted with urine and are present in blood. Using gas and liquid chromatography-mass spectrometry, we identified a series of metabolites in urine samples from humans and rats that were products of… CONTINUE READING

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