Chromatographic studies of chlorpropamide interactions with normal and glycated human serum albumin based on affinity microcolumns.

@article{Tao2018ChromatographicSO,
  title={Chromatographic studies of chlorpropamide interactions with normal and glycated human serum albumin based on affinity microcolumns.},
  author={Pingyang Tao and Z. Li and Ryan Matsuda and D. Hage},
  journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  year={2018},
  volume={1097-1098},
  pages={
          64-73
        }
}
  • Pingyang Tao, Z. Li, +1 author D. Hage
  • Published 2018
  • Chemistry, Medicine
  • Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
  • Sulfonylurea drugs have significant binding to proteins in blood, with most of this binding believed to occur with human serum albumin (HSA). High performance affinity chromatography and affinity microcolumns containing immobilized HSA were used to investigate binding by the sulfonylurea drug chlorpropamide to normal HSA and glycated HSA, which is a modified form of HSA that has an increased serum concentration in diabetes. Experiments employing frontal analysis indicated that the binding by… CONTINUE READING
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