Chromatographic separation of the venom of Bungarus multicinctus and characterization of its components.

@article{Lee1972ChromatographicSO,
  title={Chromatographic separation of the venom of Bungarus multicinctus and characterization of its components.},
  author={C. Y. Lee and S L Chang and Sen T. Kau and S. Luh},
  journal={Journal of chromatography},
  year={1972},
  volume={72 1},
  pages={
          71-82
        }
}
The venom of Bungarus multicincius has been fractionated on a CM-Sephadex C-50 column into eight major fractions by gradient elution with 0.05–1.0 M ammonium acetate buffer at pH Fraction I is identified as guanosine by its spectral data at various pH values. Fractions II and III contain postsynaptic (α-type) neurotoxins, which produce an antidepolarizing neuromuscular block by combining irreversibly with the acetylcholine receptor of the motor endplate, but they are contaminated with… CONTINUE READING

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