Chromatographic and electrophoretic characterization of protein variants.

@article{Ahrer2006ChromatographicAE,
  title={Chromatographic and electrophoretic characterization of protein variants.},
  author={Karin Ahrer and Alois Jungbauer},
  journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  year={2006},
  volume={841 1-2},
  pages={110-22}
}
Almost all proteins are expressed in several variants, also known as isoforms. Individual protein variants differ by modifications of the individual amino acid side chains, or the N- or C-terminus. Typical modifications are glycosylation, phosphorylation, acetylation, methylation, deamidation or oxidation. It is of utmost interest to either get a quantitative picture of the variants of a particular protein or to separate the variants in order to be able to identify their molecular structure… CONTINUE READING

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