Chromatographic analysis of acetohexamide binding to glycated human serum albumin.

Abstract

Acetohexamide is a drug used to treat type II diabetes and is tightly bound to the protein human serum albumin (HSA) in the circulation. It has been proposed that the binding of some drugs with HSA can be affected by the non-enzymatic glycation of this protein. This study used high-performance affinity chromatography to examine the changes in acetohexamide… (More)
DOI: 10.1016/j.jchromb.2010.08.021

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