Chromatographic Study of Azintamide in Bulk Powder and in Pharmaceutical Formulation in the Presence of Its Degradation Form.

@article{Hegazy2017ChromatographicSO,
  title={Chromatographic Study of Azintamide in Bulk Powder and in Pharmaceutical Formulation in the Presence of Its Degradation Form.},
  author={Maha Abdel-Monem Hegazy and Waleed A. Hassanain and Laila E Abdel Fattah and Hamed M. El-Fatatry},
  journal={Journal of AOAC International},
  year={2017},
  volume={100 2},
  pages={422-428}
}
Two specific, sensitive, and precise stability-indicating chromatographic methods were developed, optimized, and validated for the determination of Azintamide (AZ) in the presence of its degradation product. The first method was TLC combined with the densitometric determination of the separated bands. Separation was achieved using silica gel 60 F254 TLC plates and chloroform-acetone-glacial acetic acid (7.5 + 2.1 + 0.4, v/v/v) as the developing system. Good correlations were obtained between… CONTINUE READING