Chromatographic/mass spectrometric method for the estimation of itraconazole and its metabolite in human plasma. Application to a bioequivalence study.

@article{Grabowski2009ChromatographicmassSM,
  title={Chromatographic/mass spectrometric method for the estimation of itraconazole and its metabolite in human plasma. Application to a bioequivalence study.},
  author={Tomasz Grabowski and Anna Świerczewska and Beata Borucka and Renata Sawicka and Małgorzata Sasinowska-Motyl and Stanisław Witold Gumułka},
  journal={Arzneimittel-Forschung},
  year={2009},
  volume={59 8},
  pages={422-8}
}
A HPLC/mass spectrometry method for the estimation of itraconazole (CAS 84625-61-6, ITR) and its active metabolite hydroxyitraconazole (CAS 112559-91-8, HOX) in human plasma was developed. Terconazole (CAS 67915-31-5) was used as an internal standard. The analytical method was fully validated according to FDA and EMEA requirements. The accuracy and… CONTINUE READING