Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells.

@article{Kubicek2012ChromatintargetingSM,
  title={Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells.},
  author={Stefan Kubicek and Joshua C. Gilbert and Dina Fomina-Yadlin and Alexander D. Gitlin and Yuan Yuan and Florence F Wagner and Edward B Holson and Tuoping Luo and Timothy A. Lewis and Bradley Taylor and Supriya Sen Gupta and Alykhan F. Shamji and Bridget K Wagner and Paul A. Clemons and Stuart L. Schreiber},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 14},
  pages={5364-9}
}
Under the instruction of cell-fate-determining, DNA-binding transcription factors, chromatin-modifying enzymes mediate and maintain cell states throughout development in multicellular organisms. Currently, small molecules modulating the activity of several classes of chromatin-modifying enzymes are available, including clinically approved histone deacetylase (HDAC) and DNA methyltransferase (DNMT) inhibitors. We describe the genome-wide expression changes induced by 29 compounds targeting HDACs… CONTINUE READING