Chromatin structure regulation in transforming growth factor-beta-directed epithelial-mesenchymal transition.

@article{Blumenberg2007ChromatinSR,
  title={Chromatin structure regulation in transforming growth factor-beta-directed epithelial-mesenchymal transition.},
  author={M Blumenberg and Shujuan Gao and Kathleen G Dickman and Arthur P. Grollman and Erwin P. Bottinger and Jiri Zavadil},
  journal={Cells, tissues, organs},
  year={2007},
  volume={185 1-3},
  pages={162-74}
}
Epithelial-mesenchymal transitions (EMTs) occur in organogenesis throughout embryonic development and are recapitulated during epithelial tissue injury and in carcinoma progression. EMTs are regulated by complex, precisely orchestrated cell signaling and gene expression networks, with the participation of key developmental pathways. Here we review context-dependent modules of gene regulation by hairy/enhancer-of-split-related (H/E(spl)) repressors downstream of transforming growth factor-beta… CONTINUE READING

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