Chromatin structure of the regulatory regions of pS2 and cathepsin D genes in hormone-dependent and -independent breast cancer cell lines

@article{Giamarchi1999ChromatinSO,
  title={Chromatin structure of the regulatory regions of pS2 and cathepsin D genes in hormone-dependent and -independent breast cancer cell lines},
  author={Claire Giamarchi and Monserrat Solanas and Catherine Chailleux and Patrick Augereau and Françoise Vignon and Henri Rochefort and H{\'e}l{\`e}ne Richard-Foy},
  journal={Oncogene},
  year={1999},
  volume={18},
  pages={533-541}
}
We have compared the DNase I hypersensitivity of the regulatory region of two estrogen-regulated genes, pS2 and cathepsin D in hormone-dependent and -independent breast carcinoma cell lines. This strategy allowed the identification of two important control regions, one in pS2 and the other in cathepsin D genes. In the hormone-dependent MCF7 cell line, within the pS2 gene 5′-flanking region, we detected two major DNase I hypersensitive sites, induced by estrogens and/or IGFI: pS2-HS1, located in… CONTINUE READING
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