Chromatin structure of genes during the cell cycle.


K562 cells were separated by centrifugal elutriation into 5 fractions each of which had a unique distribution of cells at different phases of the cell cycle. A study of DNAseI sensitivity of the epsilon- and gamma-globin genes, which are expressed in these cells, and the lambda light chain immunoglobulin gene, which is not expressed, in nuclei from each of… (More)