Chromatin structure implicated in activation of HIV-1 gene expression by ultraviolet light.

We have investigated the effects of different DNA-damaging agents on HIV-1 gene expression. We find that agents that produce "bulky" DNA lesions, similar to those induced by ultraviolet light (UV), all dramatically increase HIV-1 gene expression, whereas agents that produce primarily base damage and DNA breakage, such as ionizing radiation, have little or… CONTINUE READING