Chromatin structure and transcriptional regulation of the beta-globin locus.

@article{Fu2002ChromatinSA,
  title={Chromatin structure and transcriptional regulation of the beta-globin locus.},
  author={Xiang Hui Fu and De-Pei Liu and Chih-Chuan Liang},
  journal={Experimental cell research},
  year={2002},
  volume={278 1},
  pages={1-11}
}
Chromatin structure plays a critical role in eukaryotic gene transcriptional regulation. The beta-globin locus provides an ideal system within which to study the interplay between chromatin structure and transcriptional regulation. The process of beta-globin locus activation is remarkably intricate and involves at least two distinct events: chromatin opening and gene activation. Great progress has been made in recent years in understanding how locus control regions confer high-level expression… CONTINUE READING