Chromatin structure and gene regulation in the immune system.

  title={Chromatin structure and gene regulation in the immune system.},
  author={Stephen T. Smale and Amanda G Fisher},
  journal={Annual review of immunology},
The development of the immune system and the host response to microbial infection rely on the activation and silencing of numerous, differentially expressed genes. Since the mid-1980s, a primary goal has been to identify transcription factors that regulate specific genes and specific immunological processes. More recently, there has been a growing appreciation of the role of chromatin structure in gene regulation. Before most activators of a gene access their binding sites, a transition from a… CONTINUE READING


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