Chromatin structure and evolution in the human genome

@article{Prendergast2006ChromatinSA,
  title={Chromatin structure and evolution in the human genome},
  author={James G. D. Prendergast and Harry Campbell and Nick Gilbert and Malcolm G Dunlop and Wendy A. Bickmore and C. A. M. Semple},
  journal={BMC Evolutionary Biology},
  year={2006},
  volume={7},
  pages={72 - 72}
}
Evolutionary rates are not constant across the human genome but genes in close proximity have been shown to experience similar levels of divergence and selection. The higher-order organisation of chromosomes has often been invoked to explain such phenomena but previously there has been insufficient data on chromosome structure to investigate this rigorously. Using the results of a recent genome-wide analysis of open and closed human chromatin structures we have investigated the global… CONTINUE READING

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