Chromatin structure and epigenetics.

@article{Quina2006ChromatinSA,
  title={Chromatin structure and epigenetics.},
  author={A S Quina and Marcus Buschbeck and Luciano Di Croce},
  journal={Biochemical pharmacology},
  year={2006},
  volume={72 11},
  pages={1563-9}
}
In eukaryotic cells, the DNA molecule is found in the form of a nucleoprotein complex named chromatin. The basic unit of the chromatin is the nucleosome, which comprises 147 base pairs of DNA wrapped around an octamer of core histones (made of two molecules of each H2A, H2B, H3, and H4 histones). Each nucleosome is linked to the next by small segments of linker DNA. Most chromatin is further condensated by winding in a polynucleosome fibre, which may be stabilized through the binding of histone… CONTINUE READING

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The methyl-CpG binding protein MBD1 is required for PML-RARalpha function.

Proceedings of the National Academy of Sciences of the United States of America • 2006
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