Chromatin structure: from nuclei to genes (review).

  title={Chromatin structure: from nuclei to genes (review).},
  author={Claudio Nicolini},
  journal={Anticancer research},
  volume={3 2},
Characterization of native nuclei by new unharmful biophysical methods, coupled both with the determination of lower order structures in DNA and isolated chromatin, by a variety of sophisticated physicochemical probes and with the intranuclear DNA distribution monitored in situ by high resolution image analysis, recently, point to a unique organization of chromatin-DNA from the secondary up to the quinternary level. Based on the wide range of experimental findings, hereby reviewed in details, a… CONTINUE READING