Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants.

Abstract

Chromatin-based functional genomic analyses and genomewide association studies (GWASs) together implicate enhancers as critical elements influencing gene expression and risk for common diseases. Here, we performed systematic chromatin and transcriptome profiling in human pancreatic islets. Integrated analysis of islet data with those from nine cell types… (More)
DOI: 10.1073/pnas.1317023110

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