Chromatin state dynamics confers specific therapeutic strategies in enhancer subtypes of colorectal cancer

  title={Chromatin state dynamics confers specific therapeutic strategies in enhancer subtypes of colorectal cancer},
  author={Elias Orouji and Ayush T. Raman and Anand K. Singh and Alexey V. Sorokin and Emre Arslan and Archit K. Ghosh and Jonathan Schulz and Christopher J. Terranova and Shan Jiang and Ming Tang and Mayinuer Maitituoheti and S. Carson Callahan and Praveen Barrodia and Katarzyna Tomczak and Yingda Jiang and Zhi-qin Jiang and Jennifer S Davis and Sukhen C Ghosh and Hey Min Lee and Laura Reyes-Uribe and Kyle Chang and Yusha Liu and Huiqin Chen and Ali Azhdarinia and Jeffrey Morris and Eduardo Vilar and Kendra S. Carmon and Scott Kopetz and Kunal Rai},
Objective Enhancer aberrations are beginning to emerge as a key epigenetic feature of colorectal cancers (CRC), however, a comprehensive knowledge of chromatin state patterns in tumour progression, heterogeneity of these patterns and imparted therapeutic opportunities remain poorly described. Design We performed comprehensive epigenomic characterisation by mapping 222 chromatin profiles from 69 samples (33 colorectal adenocarcinomas, 4 adenomas, 21 matched normal tissues and 11 colon cancer… Expand


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