Chromatin signatures of pluripotent cell lines

@article{Azuara2006ChromatinSO,
  title={Chromatin signatures of pluripotent cell lines},
  author={V{\'e}ronique Azuara and P. Perry and S. Sauer and M. Spivakov and H. J{\o}rgensen and R. John and Mina Gouti and Miguel Casanova and G. Warnes and M. Merkenschlager and A. Fisher},
  journal={Nature Cell Biology},
  year={2006},
  volume={8},
  pages={532-538}
}
Epigenetic genome modifications are thought to be important for specifying the lineage and developmental stage of cells within a multicellular organism. Here, we show that the epigenetic profile of pluripotent embryonic stem cells (ES) is distinct from that of embryonic carcinoma cells, haematopoietic stem cells (HSC) and their differentiated progeny. Silent, lineage-specific genes replicated earlier in pluripotent cells than in tissue-specific stem cells or differentiated cells and had… Expand
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