Chromatin signatures of cancer.

  title={Chromatin signatures of cancer.},
  author={Marc A Morgan and Ali Shilatifard},
  journal={Genes & development},
  volume={29 3},
Changes in the pattern of gene expression play an important role in allowing cancer cells to acquire their hallmark characteristics, while genomic instability enables cells to acquire genetic alterations that promote oncogenesis. Chromatin plays central roles in both transcriptional regulation and the maintenance of genomic stability. Studies by cancer genome consortiums have identified frequent mutations in genes encoding chromatin regulatory factors and histone proteins in human cancer… CONTINUE READING
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