Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals

@article{Guttman2009ChromatinSR,
  title={Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals},
  author={Mitchell Guttman and Ido Amit and Manuel Garber and Courtney French and Michael F. Lin and David M. Feldser and Maite Huarte and Or Zuk and Bryce W. Carey and John P. Cassady and Moran N. Cabili and Rudolf Jaenisch and Tarjei S. Mikkelsen and Tyler 8 Jacks and Nir Hacohen and Bradley E. Bernstein and Manolis Kellis and Aviv Regev and John L Rinn and Eric S. Lander},
  journal={Nature},
  year={2009},
  volume={458},
  pages={223-227}
}
There is growing recognition that mammalian cells produce many thousands of large intergenic transcripts. However, the functional significance of these transcripts has been particularly controversial. Although there are some well-characterized examples, most (>95%) show little evidence of evolutionary conservation and have been suggested to represent transcriptional noise. Here we report a new approach to identifying large non-coding RNAs using chromatin-state maps to discover discrete… CONTINUE READING
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