Chromatin rewiring mediates programmed evolvability via aneuploidy

@article{Brimacombe2018ChromatinRM,
  title={Chromatin rewiring mediates programmed evolvability via aneuploidy},
  author={C. Brimacombe and Jordan E. Burke and J. Parsa and Jessica N. Witchley and Laura S Burrack and H. Madhani and S. Noble},
  journal={bioRxiv},
  year={2018}
}
Eukaryotes have evolved elaborate mechanisms to ensure that chromosomes segregate with high fidelity during mitosis and meiosis1, and yet specific aneuploidies can be adaptive during environmental stress2,3. Here, we identify a chromatin-based system for inducible aneuploidy in a human pathogen. Candida albicans utilizes chromosome missegregation to acquire resistance to antifungal drugs4,5 and for ploidy reduction after mating6. We discovered that the ancestor of C. albicans and two related… Expand
2 Citations
Aneuploidy Enables Cross-Adaptation to Unrelated Drugs
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