Chromatin remodelling complex dosage modulates transcription factor function in heart development

Abstract

Dominant mutations in cardiac transcription factor genes cause human inherited congenital heart defects (CHDs); however, their molecular basis is not understood. Interactions between transcription factors and the Brg1/Brm-associated factor (BAF) chromatin remodelling complex suggest potential mechanisms; however, the role of BAF complexes in cardiogenesis… (More)
DOI: 10.1038/ncomms1187

Topics

7 Figures and Tables

Cite this paper

@inproceedings{Takeuchi2011ChromatinRC, title={Chromatin remodelling complex dosage modulates transcription factor function in heart development}, author={Jun Takeuchi and Xin Lou and Jeffrey M. Alexander and Hiroe Sugizaki and Paul Delgado-Olguin and Alisha K. Holloway and Alessandro Mori and John N. Wylie and Chantilly A Munson and Yonghong Zhu and Yu-qing Zhou and Ru-Fang Yeh and R. Mark Henkelman and Richard P. Harvey and Daniel Metzger and Pierre Chambon and Didier Y. R. Stainier and Katherine S. Pollard and Ian C Scott and Benoit G Bruneau}, booktitle={Nature communications}, year={2011} }