Chromatin remodelling complex dosage modulates transcription factor function in heart development

@inproceedings{Takeuchi2011ChromatinRC,
  title={Chromatin remodelling complex dosage modulates transcription factor function in heart development},
  author={Jun Takeuchi and X. Z. Lou and Jeffrey M. Alexander and Hiroe Sugizaki and Paul Delgado-Olgu{\'i}n and Alisha K. Holloway and Alessandro D. Mori and John N. Wylie and Chantilly A Munson and Yonghong Zhu and Yu-qing Zhou and Ru-Fang Yeh and R. Mark Henkelman and Richard P. Harvey and Daniel Metzger and Pierre Chambon and Didier Y. R. Stainier and Katherine S. Pollard and Ian C Scott and Benoit G Bruneau},
  booktitle={Nature communications},
  year={2011}
}
Dominant mutations in cardiac transcription factor genes cause human inherited congenital heart defects (CHDs); however, their molecular basis is not understood. Interactions between transcription factors and the Brg1/Brm-associated factor (BAF) chromatin remodelling complex suggest potential mechanisms; however, the role of BAF complexes in cardiogenesis is not known. In this study, we show that dosage of Brg1 is critical for mouse and zebrafish cardiogenesis. Disrupting the balance between… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 75 extracted citations

Immediate type hypersensitivity and late phase reaction occurred consecutively in a patient receiving ethambutol and levofloxacin

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology • 2018
View 1 Excerpt

hace1 Influences zebrafish cardiac development via ROS-dependent mechanisms.

Developmental dynamics : an official publication of the American Association of Anatomists • 2018

References

Publications referenced by this paper.
Showing 1-10 of 56 references

Chromatin remodeling in heart development.

Current opinion in genetics & development • 2010

Tbx5-dependent pathway regulating diastolic function in congenital heart disease.

Proceedings of the National Academy of Sciences of the United States of America • 2008

Similar Papers

Loading similar papers…