Chromatin remodelling complex dosage modulates transcription factor function in heart development

  title={Chromatin remodelling complex dosage modulates transcription factor function in heart development},
  author={Jun Takeuchi and X. Z. Lou and Jeffrey M. Alexander and Hiroe Sugizaki and Paul Delgado-Olgu{\'i}n and Alisha K. Holloway and Alessandro D. Mori and John N. Wylie and Chantilly A Munson and Yonghong Zhu and Yu-qing Zhou and Ru-Fang Yeh and R. Mark Henkelman and Richard P. Harvey and Daniel Metzger and Pierre Chambon and Didier Y. R. Stainier and Katherine S. Pollard and Ian C Scott and Benoit G Bruneau},
  booktitle={Nature communications},
Dominant mutations in cardiac transcription factor genes cause human inherited congenital heart defects (CHDs); however, their molecular basis is not understood. Interactions between transcription factors and the Brg1/Brm-associated factor (BAF) chromatin remodelling complex suggest potential mechanisms; however, the role of BAF complexes in cardiogenesis is not known. In this study, we show that dosage of Brg1 is critical for mouse and zebrafish cardiogenesis. Disrupting the balance between… CONTINUE READING

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