Chromatin remodelling and nuclear reprogramming at the onset of embryonic development in mammals.

@article{Renard1998ChromatinRA,
  title={Chromatin remodelling and nuclear reprogramming at the onset of embryonic development in mammals.},
  author={J. P. Renard},
  journal={Reproduction, fertility, and development},
  year={1998},
  volume={10 7-8},
  pages={573-80}
}
  • J. P. Renard
  • Published 1998 in Reproduction, fertility, and development
Two main strategies are used to produce cloned mammals. The first involves the condensation of donor chromatin into chromosomes directly exposed to the recipient cytoplasm, whereas the second leaves the donor nucleus in interphase until the time of the first mitosis. Both strategies, which induce marked changes in chromatin organization, allow full reprogrammation of somatic-differentiated fetal and adult cells. This paper reviews some of the recent data that contribute to our understanding of… CONTINUE READING
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