Chromatin remodelling and actin organisation

@article{Farrants2008ChromatinRA,
  title={Chromatin remodelling and actin organisation},
  author={Ann-Kristin {\"O}stlund Farrants},
  journal={FEBS Letters},
  year={2008},
  volume={582}
}

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β- and γ-Actins in the nucleus of human melanoma A375 cells

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Nuclear functions of actin.

Nuclear actin works in conjunction with different types of actin-binding proteins that regulate actin function and bridge interactions between actin and other nuclear components.
...

References

SHOWING 1-10 OF 100 REFERENCES

Nuclear actin and actin-related proteins in chromatin remodeling.

The observation that the BAF chromatin remodeling complex, in which actin was originally identified, is also a human tumor suppressor complex necessary for the actions of the retinoblastoma protein indicates that the study of nuclear actin is likely to contribute to understanding cell growth control.

The regulation of ATP-dependent nucleosome remodelling factors.

Molecular functions of nuclear actin in transcription

A general model for actin in RNA polymerase II transcription is discussed whereby actin works as a conformational switch in conjunction with specific adaptors to facilitate the remodeling of large macromolecular assemblies at the promoter and along the active gene.

INO80 subfamily of chromatin remodeling complexes.

Composition and functional specificity of SWI2/SNF2 class chromatin remodeling complexes.

The chromatin remodelling complex WSTF–SNF2h interacts with nuclear myosin 1 and has a role in RNA polymerase I transcription

It is shown by biochemical fractionation of nuclear extracts, protein–protein interaction studies and chromatin immunoprecipitation assays that NM1 is part of a multiprotein complex that contains WICH, a chromatin remodelling complex containing WSTF and SNF2h.

Actin and ARPs: action in the nucleus.

Actin is part of pre-initiation complexes and is necessary for transcription by RNA polymerase II

A fundamental role for actin in the initiation of transcription by RNA polymerase II is suggested after it was demonstrated that antibodies directed against β-actin, but not muscle actin, inhibited transcription in vivo and in vitro.

Phosphatidylinositol-dependent actin filament binding by the SWI/SNF-like BAF chromatin remodeling complex

It is shown that the mammalian SWI/SNF-like BAF complex binds to phosphatidylinositol 4,5-bisphosphate (PIP2) micelles and PIP2-containing mixed lipid vesicles, and that PIP 2 binding allows the complex to associate with actin pointed ends and branch points.
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