Co-transcriptional nuclear actin dynamics
By focusing on the multiple tasks performed by actin and actin-binding proteins, possible models of how actin dynamics controls the different phases of the RNA polymerase II transcription cycle are being identified.
NuA4 and SWR1-C: two chromatin-modifying complexes with overlapping functions and components.
- BiologyBiochemistry and cell biology = Biochimie et biologie cellulaire
This review will summarize recent findings about NuA4 and SWR1-C and focus on the connection between these complexes by investigating their physical and functional interactions through eukaryotic evolution.
Actin on DNA—An ancient and dynamic relationship
A common feature to the novel modes of actin utilization is the connection between actin and DNA, and here it is aimed to review the recent literature to explore how this connection is exploited in different contexts.
Active maintenance of nuclear actin by importin 9 supports transcription
- BiologyProceedings of the National Academy of Sciences
It is demonstrated that cytoplasmic and nuclear actin pools are dynamically connected and the nuclear import and export mechanisms of actin are identified, which suggest an active transport mechanism in both directions.
The long journey of actin and actin-associated proteins from genes to polysomes
- Biology, ChemistryCellular and Molecular Life Sciences
Evidence on the involvement of actin and actin-associated proteins in RNA biogenesis is presented and integrative models supporting the view that actin facilitates coordination of the different steps in gene expression are proposed.
Actin, actin-binding proteins, and actin-related proteins in the nucleus
- BiologyHistochemistry and Cell Biology
An overview of the wide range of information that is now available about actin, act in-binding, and actin-related proteins in the nucleus is provided.
Subnuclear compartmentalization and function of actin and nuclear Myosin I in plants
It is shown that actin isoforms with distinct solubilities are present in onion nuclei with a consistent subnuclear compartmentalization, although actin is also distributed diffusely in the nucleus and nucleolus as well as accumulating in a subset of the Cajal bodies.
Exploring Secrets of Nuclear Actin Involvement in the Regulation of Gene Transcription and Genome Organization
The dynamics of actin, the coordinated assembly and disassembly of actIn filaments in response to cellular and extracellular signaling, is critical for the diverse functions of act in eukaryotic cells and is tightly regulated by a plethora ofActin-binding proteins (ABPs) in the cytoplasm.
β- and γ-Actins in the nucleus of human melanoma A375 cells
- BiologyHistochemistry and Cell Biology
It is shown that, in contrast to the cytoplasm, the majority of endogenous nuclear actin is unpolymerized in human melanoma A375 cells, and β- and γ-non-muscle actin isoforms are present in nuclei of these cells.
SHOWING 1-10 OF 100 REFERENCES
Nuclear actin and actin-related proteins in chromatin remodeling.
- BiologyAnnual review of biochemistry
The observation that the BAF chromatin remodeling complex, in which actin was originally identified, is also a human tumor suppressor complex necessary for the actions of the retinoblastoma protein indicates that the study of nuclear actin is likely to contribute to understanding cell growth control.
The regulation of ATP-dependent nucleosome remodelling factors.
- BiologyMutation research
Molecular functions of nuclear actin in transcription
- BiologyThe Journal of cell biology
A general model for actin in RNA polymerase II transcription is discussed whereby actin works as a conformational switch in conjunction with specific adaptors to facilitate the remodeling of large macromolecular assemblies at the promoter and along the active gene.
INO80 subfamily of chromatin remodeling complexes.
- Biology, ChemistryMutation research
Composition and functional specificity of SWI2/SNF2 class chromatin remodeling complexes.
- BiologyBiochimica et biophysica acta
The chromatin remodelling complex WSTF–SNF2h interacts with nuclear myosin 1 and has a role in RNA polymerase I transcription
- BiologyEMBO reports
It is shown by biochemical fractionation of nuclear extracts, protein–protein interaction studies and chromatin immunoprecipitation assays that NM1 is part of a multiprotein complex that contains WICH, a chromatin remodelling complex containing WSTF and SNF2h.
Rapid and Phosphoinositol-Dependent Binding of the SWI/SNF-like BAF Complex to Chromatin after T Lymphocyte Receptor Signaling
- Biology, ChemistryCell
Actin is part of pre-initiation complexes and is necessary for transcription by RNA polymerase II
- BiologyNature Cell Biology
A fundamental role for actin in the initiation of transcription by RNA polymerase II is suggested after it was demonstrated that antibodies directed against β-actin, but not muscle actin, inhibited transcription in vivo and in vitro.
Phosphatidylinositol-dependent actin filament binding by the SWI/SNF-like BAF chromatin remodeling complex
- Biology, ChemistryProceedings of the National Academy of Sciences of the United States of America
It is shown that the mammalian SWI/SNF-like BAF complex binds to phosphatidylinositol 4,5-bisphosphate (PIP2) micelles and PIP2-containing mixed lipid vesicles, and that PIP 2 binding allows the complex to associate with actin pointed ends and branch points.