Chromatin remodeling in the aging genome of Drosophila.

@article{Wood2010ChromatinRI,
  title={Chromatin remodeling in the aging genome of Drosophila.},
  author={Jason G Wood and Sara Hillenmeyer and Charles Lawrence and Chengyi Chang and Suzanne Hosier and Will Lightfoot and Eric Milan Mukherjee and Nan Jiang and Christoph Schorl and Alexander S. Brodsky and Nicola Neretti and Stephen L. Helfand},
  journal={Aging cell},
  year={2010},
  volume={9 6},
  pages={
          971-8
        }
}
Chromatin structure affects the accessibility of DNA to transcription, repair, and replication. Changes in chromatin structure occur during development, but less is known about changes during aging. We examined the state of chromatin structure and its effect on gene expression during aging in Drosophila at the whole genome and cellular level using whole-genome tiling microarrays of activation and repressive chromatin marks, whole-genome transcriptional microarrays and single-cell… CONTINUE READING
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