Chromatin remodeling in mammalian zygotes.

  title={Chromatin remodeling in mammalian zygotes.},
  author={Sally D. Perreault},
  journal={Mutation research},
  volume={296 1-2},
With sperm-egg fusion at the time of fertilization the gamete nuclei are remodeled from genetically quiescent structures into pronuclei capable of DNA synthesis. Features of this process that are critical to insure the genetic integrity of the zygote and the success of subsequent embryonic development include: oocyte responses that prevent polyspermy; completion of the 2nd meiotic division by the oocyte; exchange of proteins in the sperm nucleus; and, remodelling of the oocyte chromosomes and… CONTINUE READING

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