Chromatin remodeling by ISW2 and SWI/SNF requires DNA translocation inside the nucleosome

@article{Zofall2006ChromatinRB,
  title={Chromatin remodeling by ISW2 and SWI/SNF requires DNA translocation inside the nucleosome},
  author={Martin Zofall and Jim Persinger and Stefan R Kassabov and Blaine Bartholomew},
  journal={Nature Structural &Molecular Biology},
  year={2006},
  volume={13},
  pages={339-346}
}
Chromatin-remodeling complexes regulate access to nucleosomal DNA by mobilizing nucleosomes in an ATP-dependent manner. In this study, we find that chromatin remodeling by SWI/SNF and ISW2 involves DNA translocation inside nucleosomes two helical turns from the dyad axis at superhelical location-2. DNA translocation at this internal position does not… CONTINUE READING