Chromatin remodeling around nucleosome-free regions leads to repression of noncoding RNA transcription.

@article{Yadon2010ChromatinRA,
  title={Chromatin remodeling around nucleosome-free regions leads to repression of noncoding RNA transcription.},
  author={Adam N. Yadon and Daniel P Van de Mark and Ryan S Basom and Jeffrey J. Delrow and Iestyn Whitehouse and Toshio Tsukiyama},
  journal={Molecular and cellular biology},
  year={2010},
  volume={30 21},
  pages={
          5110-22
        }
}
Nucleosome-free regions (NFRs) at the 5' and 3' ends of genes are general sites of transcription initiation for mRNA and noncoding RNA (ncRNA). The presence of NFRs within transcriptional regulatory regions and the conserved location of transcription start sites at NFRs strongly suggest that the regulation of NFRs profoundly affects transcription initiation. To date, multiple factors are known to facilitate transcription initiation by positively regulating the formation and/or size of NFRs in… CONTINUE READING
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