Chromatin remodeling and control of cell proliferation by progestins via cross talk of progesterone receptor with the estrogen receptors and kinase signaling pathways.

@article{Vicent2006ChromatinRA,
  title={Chromatin remodeling and control of cell proliferation by progestins via cross talk of progesterone receptor with the estrogen receptors and kinase signaling pathways.},
  author={Guillermo P Vicent and Cecilia Ballar{\'e} and Roser Zaur{\'i}n and Patricia Esther Sarag{\"u}eta and Miguel Beato},
  journal={Annals of the New York Academy of Sciences},
  year={2006},
  volume={1089},
  pages={59-72}
}
Transcription from the mouse mammary tumor virus (MMTV) promoter can be induced by glucocorticoids or progestins. Progesterone treatment of cultured cells carrying an integrated single copy of an MMTV transgene leads to recruitment of progesterone receptor (PR), SWI/SNF, and SNF2h-related complexes to MMTV promoter. Recruitment is accompanied by selective displacement of histones H2A and H2B from the nucleosome B. In nucleosomes assembled on promoter sequences, SWI/SNF displaces histones H2A… CONTINUE READING