Chromatin regulation and genome maintenance by mammalian SIRT6.

  title={Chromatin regulation and genome maintenance by mammalian SIRT6.},
  author={Ruth I. Tennen and Katrin F. Chua},
  journal={Trends in biochemical sciences},
  volume={36 1},
Saccharomyces cerevisiae Sir2 is an NAD(+)-dependent histone deacetylase that links chromatin silencing to genomic stability, cellular metabolism and lifespan regulation. In mice, deficiency for the Sir2 family member SIRT6 leads to genomic instability, metabolic defects and degenerative pathologies associated with aging. Until recently, SIRT6 was an orphan enzyme whose catalytic activity and substrates were unclear. However, new mechanistic insights have come from the discovery that SIRT6 is a… CONTINUE READING
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