Chromatin regulates origin activity in Drosophila follicle cells

  title={Chromatin regulates origin activity in Drosophila follicle cells},
  author={Bhagwan Das Aggarwal and Brian R Calvi},
It is widely believed that DNA replication in multicellular animals (metazoa) begins at specific origins to which a pre-replicative complex (pre-RC) binds. Nevertheless, a consensus sequence for origins has yet to be identified in metazoa. Origin identity can change during development, suggesting that there are epigenetic influences. A notable example of developmental specificity occurs in Drosophila, where somatic follicle cells of the ovary transition from genomic replication to exclusive re… CONTINUE READING
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