Chromatin redistribution of the DEK oncoprotein represses hTERT transcription in leukemias.

@article{Karam2014ChromatinRO,
  title={Chromatin redistribution of the DEK oncoprotein represses hTERT transcription in leukemias.},
  author={Maroun Karam and Morgan Th{\'e}noz and Val{\'e}rie Capraro and J. Robin and Christiane Pinatel and Agn{\`e}s Lançon and Perrine Galia and David Sibon and X. Thomas and Sophie Ducastelle-Lepr{\^e}tre and Franck Emmanuel Nicolini and Mohamed El-Hamri and Youcef Chelghoun and E Wattel and Franck Mortreux},
  journal={Neoplasia},
  year={2014},
  volume={16 1},
  pages={21-30}
}
Although numerous factors have been found to modulate hTERT transcription, the mechanism of its repression in certain leukemias remains unknown. We show here that DEK represses hTERT transcription through its enrichment on the hTERT promoter in cells from chronic and acute myeloid leukemias, chronic lymphocytic leukemia, but not acute lymphocytic leukemias where hTERT is overexpressed. We isolated DEK from the hTERT promoter incubated with nuclear extracts derived from fresh acute myelogenous… CONTINUE READING

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