Chromatin organization of gammaherpesvirus latent genomes.

  title={Chromatin organization of gammaherpesvirus latent genomes.},
  author={Italo Tempera and Paul M. Lieberman},
  journal={Biochimica et biophysica acta},
  volume={1799 3-4},
The gammaherpesviruses are a subclass of the herpesvirus family that establish stable latent infections in proliferating lymphoid and epithelial cells. The latent genomes are maintained as multicopy chromatinized episomes that replicate in synchrony with the cellular genome. Importantly, most of the episomes do not integrate into the host chromosome. Therefore, it is essential that the viral "minichromosome" establish a chromatin structure that is suitable for gene expression, DNA replication… CONTINUE READING


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