• DOI:10.1038/nature11273
Corpus ID: 205229634

Chromatin organization is a major influence on regional mutation rates in human cancer cells

@article{SchusterBoeckler2012ChromatinOI,
  title={Chromatin organization is a major influence on regional mutation rates in human cancer cells},
  author={B. Schuster-Boeckler and Ben Lehner},
  journal={Nature},
  year={2012},
  volume={488},
  pages={504-507}
}

• B. Schuster-Boeckler, Ben Lehner
• Published 2012
• Biology, Medicine
• Nature

Cancer genome sequencing provides the first direct information on how mutation rates vary across the human genome in somatic cells. Testing diverse genetic and epigenetic features, here we show that mutation rates in cancer genomes are strikingly related to chromatin organization. Indeed, at the megabase scale, a single feature—levels of the heterochromatin-associated histone modification H3K9me3—can account for more than 40% of mutation-rate variation, and a combination of features can account… Expand

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