Chromatin occupancy of transcription factor 7-like 2 (TCF7L2) and its role in hepatic glucose metabolism

@article{Norton2011ChromatinOO,
  title={Chromatin occupancy of transcription factor 7-like 2 (TCF7L2) and its role in hepatic glucose metabolism},
  author={Luke Norton and Marcel J. Fourcaudot and Muhammad Abdul-Ghani and Deidre A. Winnier and Farhad Mehta and Christopher P. Jenkinson and Ralph A DeFronzo},
  journal={Diabetologia},
  year={2011},
  volume={54},
  pages={3132-3142}
}
The mechanisms by which transcription factor 7-like 2 (TCF7L2) regulates the pathways that are important in the pathogenesis of type 2 diabetes are unknown. We therefore examined the role of TCF7L2 in hepatic glucose production (HGP) in vitro and characterised the whole-genome chromatin occupancy of TCF7L2 in hepatocytes. We investigated the effect of TCF7L2 silencing and overexpression on HGP from gluconeogenic precursors and used chromatin-immunoprecipitation (ChIP) combined with massively… CONTINUE READING