Chromatin measurements reveal contributions of synthesis and decay to steady-state mRNA levels

@inproceedings{Tippmann2012ChromatinMR,
  title={Chromatin measurements reveal contributions of synthesis and decay to steady-state mRNA levels},
  author={Sylvia C Tippmann and Robert Ivanek and Dimos Gaidatzis and Anne Sch{\"o}ler and Leslie Hoerner and Erik van Nimwegen and Peter F. Stadler and Michael B. Stadler and Dirk Sch{\"u}beler},
  booktitle={Molecular systems biology},
  year={2012}
}
Messenger RNA levels in eukaryotes are controlled by multiple consecutive regulatory processes, which can be classified into two layers: primary transcriptional regulation at the chromosomal level and secondary, co- and post-transcriptional regulation of the mRNA. To identify the individual contribution of these layers to steady-state RNA levels requires separate quantification. Using mouse as a model organism, we show that chromatin features are sufficient to model RNA levels but with… CONTINUE READING