Chromatin loop domain organization within the 4q35 locus in facioscapulohumeral dystrophy patients versus normal human myoblasts.

@article{Petrov2006ChromatinLD,
  title={Chromatin loop domain organization within the 4q35 locus in facioscapulohumeral dystrophy patients versus normal human myoblasts.},
  author={Andrei Petrov and Iryna Pirozhkova and Gilles Carnac and Dalila Laoudj and Marc Lipinski and Yegor S Vassetzky},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 18},
  pages={6982-7}
}
Fascioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant neuromuscular disorder linked to partial deletion of integral numbers of a 3.3 kb polymorphic repeat, D4Z4, within the subtelomeric region of chromosome 4q. Although the relationship between deletions of D4Z4 and FSHD is well established, how this triggers the disease remains unclear. We have mapped the DNA loop domain containing the D4Z4 repeat cluster in human primary myoblasts and in murine-human hybrids. A nuclear… CONTINUE READING

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Chromatin: A Practical Approach, ed

  • S. M. Gasser, Y. S. Vassetzky
  • 1998

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