Chromatin loading of Smc5/6 is induced by DNA replication but not by DNA double-strand breaks.

@article{Tsuyama2006ChromatinLO,
  title={Chromatin loading of Smc5/6 is induced by DNA replication but not by DNA double-strand breaks.},
  author={Takashi Tsuyama and Katsutoshi Inou and Masayuki Seki and Takahiko Seki and Yuji Kumata and Takayuki Kobayashi and Keiji Richard Kimura and Fumio Hanaoka and Takemi Enomoto and Shusuke Tada},
  journal={Biochemical and biophysical research communications},
  year={2006},
  volume={351 4},
  pages={935-9}
}
Smc6, a member of the structural maintenance of chromosomes (SMC) family of proteins, forms a complex with related Smc5. Genetic analyses of yeast have demonstrated the involvement of Smc6 in DNA repair and checkpoint responses. In this study, we investigated the role of the Smc5/6 complex in higher eukaryotes by analyzing its behavior in Xenopus laevis egg extracts. Smc5/6 was loaded onto chromatin during DNA replication in a manner dependent on the initiation of DNA synthesis, and it… CONTINUE READING

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