Chromatin landscape dynamics of the Il4-Il13 locus during T helper 1 and 2 development.

@article{Baguet2004ChromatinLD,
  title={Chromatin landscape dynamics of the Il4-Il13 locus during T helper 1 and 2 development.},
  author={Aur{\'e}lie Baguet and Mark Bix},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 31},
  pages={11410-5}
}
Il4 and Il13 encode the canonical T helper 2 (TH2) cytokines responsible both for promoting immune responses against extracellular pathogens and, when misregulated, causing allergic and autoimmune disease. The expression potential of these genes undergoes developmentally programmed repression and enhancement during commitment of naïve CD4+ T cells to the mature T helper 1 (TH1) and TH2 fates, respectively. Thus, like the globin locus, the TH2 cytokine locus provides a highly tractable system to… CONTINUE READING
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