Chromatin insulators and boundaries: effects on transcription and nuclear organization.

  title={Chromatin insulators and boundaries: effects on transcription and nuclear organization.},
  author={T. Gerasimova and V. Corces},
  journal={Annual review of genetics},
  • T. Gerasimova, V. Corces
  • Published 2001
  • Biology, Medicine
  • Annual review of genetics
  • Chromatin boundaries and insulators are transcriptional regulatory elements that modulate interactions between enhancers and promoters and protect genes from silencing effects by the adjacent chromatin. Originally discovered in Drosophila, insulators have now been found in a variety of organisms, ranging from yeast to humans. They have been found interspersed with regulatory sequences in complex genes and at the boundaries between active and inactive chromatin. Insulators might modulate… CONTINUE READING
    174 Citations

    Figures and Topics from this paper.

    Chromatin insulators.
    • 154
    • Highly Influenced
    • PDF
    Genomic insulators: connecting properties to mechanism.
    • 151
    The nuclear pore complex and chromatin boundaries.
    • 6
    • PDF
    Insulators and promoters: closer than we think
    • 150
    Mechanisms of insulator function in gene regulation and genomic imprinting.
    • 30
    Chromatin Insulators: Master Regulators of the Eukaryotic Genome
    Chromatin insulation by a transcriptional activator
    • 28
    • PDF
    Nongenic transcription, gene regulation and action at a distance
    • P. Cook
    • Medicine, Biology
    • Journal of Cell Science
    • 2003
    • 73
    • PDF


    Effects of cis arrangement of chromatin insulators on enhancer-blocking activity.
    • 189
    • PDF
    Insulators and boundaries: versatile regulatory elements in the eukaryotic genome.
    • 399
    A chromatin insulator determines the nuclear localization of DNA.
    • 340
    • PDF
    The gypsy insulator of Drosophila affects chromatin structure in a directional manner.
    • 27
    • PDF
    Loss of insulator activity by paired Su(Hw) chromatin insulators.
    • 192
    Genetic and molecular analysis of the gypsy chromatin insulator of Drosophila.
    • 121
    • PDF
    The role of insulator elements in defining domains of gene expression.
    • P. Geyer
    • Biology, Medicine
    • Current opinion in genetics & development
    • 1997
    • 211
    Polycomb and Trithorax Group Proteins Mediate the Function of a Chromatin Insulator
    • 225
    The boundaries of the silenced HMR domain in Saccharomyces cerevisiae.
    • 374
    • PDF
    Distant liaisons: long-range enhancer-promoter interactions in Drosophila.
    • D. Dorsett
    • Biology, Medicine
    • Current opinion in genetics & development
    • 1999
    • 194