Chromatin insulation by a transcriptional activator.

@article{Sutter2003ChromatinIB,
  title={Chromatin insulation by a transcriptional activator.},
  author={Nathan B. Sutter and David Scalzo and Steven Fiering and Mark Groudine and David I. K. Martin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 3},
  pages={1105-10}
}
In eukaryotic genomes, transcriptionally active regions are interspersed with silent chromatin that may repress genes in its vicinity. Chromatin insulators are elements that can shield a locus from repressive effects of flanking chromatin. Few such elements have been characterized in higher eukaryotes, but transcriptional activating elements are an invariant feature of active loci and have been shown to suppress transgene silencing. Hence, we have assessed the ability of a transcriptional… CONTINUE READING
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