Chromatin insulation by a transcriptional activator.

  title={Chromatin insulation by a transcriptional activator.},
  author={Nathan B. Sutter and David Scalzo and Steven Fiering and Mark Groudine and David I. K. Martin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={100 3},
In eukaryotic genomes, transcriptionally active regions are interspersed with silent chromatin that may repress genes in its vicinity. Chromatin insulators are elements that can shield a locus from repressive effects of flanking chromatin. Few such elements have been characterized in higher eukaryotes, but transcriptional activating elements are an invariant feature of active loci and have been shown to suppress transgene silencing. Hence, we have assessed the ability of a transcriptional… CONTINUE READING
10 Citations
3 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 10 extracted citations


Publications referenced by this paper.
Showing 1-3 of 3 references cgi doi

  • Sutter
  • Cell. Biol
  • 2001

Molecular Cloning: A Laboratory Manual (Cold

  • J. Sambrook, E. F. Fritsch, T. Maniatis
  • 1989

Cold Spring Harbor Symp

  • H. Weintraub, S. J. Flint, I. M. Leffak, M. Groudine, R. M. Grainger
  • Quant . Biol .
  • 1978

Similar Papers

Loading similar papers…